ABSTRACT
O conteúdo histamínico pulmonar de ratos submetidos ao edema pulmonar agudo adrenalínico näo foi afetado pelos antiinflamatórios tremaril e ácido acetilsalicílico. Porém, os animais previamente tratados com indometacina, na dose única de 50 mg/kg, assim como nas três doses de 25 mg/kg, apresentaram uma variaçäo estatisticamente significativa do conteúdo histamínico pulmonar. O mesmo fato foi observado com os animais pré-tratados com fenazona (10, 40 e 80 mg/kg). Os animais pré-tratados com fenilbutazona, nas doses de 10 e 80 mg/kg e aqueles com oxifenilbutazona (20 mg/kg) apresentaram uma variaçäo estatisticamente significativa do conteúdo histamínico pulmonar
Subject(s)
Animals , Male , Rats , Antipyrine/pharmacology , Aspirin/pharmacology , Histamine/analysis , Indomethacin/pharmacology , Oxyphenbutazone/pharmacology , Phenylbutazone/pharmacology , Pulmonary Edema/chemically induced , Anti-Inflammatory Agents/pharmacology , EpinephrineABSTRACT
The aim of the present work was a study of the acute toxicity, the anti-inflammatory activity as the analgesic potency of salicylates, oxyphenbutazone, hydrocortisone and propranolol The L.D[50] was found to be 300 mg/kg., 460 mg/kg., 750 mg/kg. and 36 mg/kg respectively. All tested drugs induced a significant anti-inflammatory activity sod. Salicylate was the most potent, while propranolol was the least effective one. Sod. salicylate, hydrocortisone and oxyphenbutazone exerted a significant analgesic activity following the hot plate method, but by using the tail compression test only sod. salicylate exerted analgesic activity